To determine the functional capillary density, we classified capillaries only as perfused or stopped, with more liberal criteria for perfusion than in the study of Lam and colleagues (any flow over a three-minute period compared to no more than 30 seconds of interrupted flow over a two-minute period).
Perfusion MRI allows the study of blood supply in tumours via imaging of tumour vascularity either by IV contrast medium injection (Dynamic Susceptibility Contrast Imaging DSCI, or Dynamic Contrast Enhancement DCE) or by endogenous contrast mechanism (Arterial Spin Labelling ASL) [ 15].
In conclusion, these preliminary results support the view that [18F]fluciclatide binding (retention) is not dependent on perfusion, highlighting the potential of this radiotracer in the study of receptors expressed on the neovasculature.
Moreover, laser Doppler fluxmetry does not take into account the type of microvessels under study, their morphology, the direction of flow and, more importantly, the heterogeneity of perfusion; the latter is a key component in the study of microcirculation, especially in sepsis.
In addition, the study of tumor perfusion in representative lesions measured by dynamic contrast-enhanced magnetic resonance imaging demonstrated decreased tumor vascularization in most patients.
This combined with a lack of any observed effect of dopaminergic medication on perfusion in the present study indicate that the role of dopaminergic mediated processes on visual function in dementia with Lewy bodies is more complex and may depend on other factors, for example, the severity of co-associated cortical neuro-degeneration and/or concurrent changes in other neurotransmitter systems.
Assessing the impact of radiation-induced changes in soft tissue density ∕ thickness on the study of radiation-induced perfusion changes in the lung and heart.
Single photon emission computed tomography (SPECT) using a number of neutral lipophilic radiotracers like 99mTechnetium-ethylene-cysteine-dimer 99mTc-ECD 99mTechnetium-ethylene-cysteine-dimer 99mTc-ECD 99mTechnetium-ethylene-cysteine-dimer 99mTc-ECD 99mTechnetium-ethylene-cysteine-dimer 99mTc-ECD 99mTechnetium-ethylene-cysteine-dimer 99mTc-ECDrvous system [ 6, 9].
Because of the previously described roll-off phenomenon under high-flow conditions, which in mice are already found in resting conditions, we did not aim for absolute quantification of myocardial perfusion in this study.
The obtained data allow to assume that the integrated use of PET with 18F FDG and 18F FCh and CT perfusion in a single study improves the differential diagnostic possibilities of PET/CT diagnostics, which can find application in planning and prognosis of the disease.
