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Visual and semiquantitative analyses of all rest and stress Rb myocardial activity images revealed normal uniform perfusion in the majority of the segments (1,114/1,122 or 99.3%).
Finally, in our group of patients with mild CAD with homogeneous myocardial perfusion in the majority of segments, MBF quantification with either Rb or O-water revealed significantly decreased MBF, MFR and CVR as compared to control subjects.
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In support of a poor correlation between macrocirculatory endpoints and tissue perfusion in shock, the majority of critically ill patients with sepsis continued to exhibit signs of tissue hypoperfusion despite reaching macrocirculatory endpoints (for example, mean arterial blood pressure of at least 65 mm Hg and central venous pressure of at least 8 mm Hg).
Despite striking data on the lack of a relationship between macrocriculatory variables and tissue perfusion in shock, the majority of recommendations and physicians still focus on these variables as resuscitation endpoints for the care of patients in shock.
The observed lack of correlations between the perfusion and metabolism parameters in the majority of lesions could partly be due to the absence of motion correction of the PET images in our study.
It therefore seems that by avoiding decreases in cardiac output, splanchnic perfusion can be preserved in the majority of the patients.
Efforts are underway to define a threshold of perfusion below which the majority of anastomoses will not heal.
Again there were numerous differences in the clinical and perfusion protocols between this trial and those in widespread use in the majority of centres currently[ 14].
In the majority of experimental studies, fluid infusion did not restore intestinal mucosal perfusion, even though systemic and mesenteric parameters were improved [ 18, 19].
The DW technique used by us comprised multiple and higher b values than in the majority of prior studies and omitted the lowest b value of 0, leading to some decrease of the perfusion effect.
Third, this study focused on MAP rather than mean perfusion pressure of the kidney, as intra-abdominal pressure (IAP) was measured only in a few patients, and information on IAP levels in the majority of patients was lacking.
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