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Unbound drug molecules present in the synovial fluid will diffuse through the semi-permeable membrane into the perfusate, down their concentration gradient.
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Any compound in the perfusate will diffuse down that compound's concentration into the extracellular space of the brain; therefore, microdialysis (sometimes called retrodialysis in this context) may provide a therapeutic opportunity for local drug delivery.
A carrier liquid, the perfusate, is perfused into the probe.
The oxygenation chamber in our perfusion system maintains perfusate Po2 > 600 mmHg.
The perfusion can be carried out with a single liver passage of the perfusate (non-recirculating "open" system of perfusion) or the perfusate can be recirculated ("closed" system).
Lactate concentration was measured in perfusate samples collected from isolated perfused hearts.
To test the hypothesis of a role for exogenous surfactant in down-modulating systemic inflammation in ALI, sequential lung perfusate samples, as a surrogate for systemic inflammation, were analyzed for IL-6 concentrations.
Conclusion: While the pump infusion techniques produce uniform and homogeneous perfusates, gravity technique was found to deliver a variable content perfusate making difficult the control of cumulative perfused activity, and perilous the planning administration of partial activities following dose adjustments.
The perfusion medium consisted of a custom-made perfusate [ 15] and autologous blood.
Switch the perfusate to Lithium buffer with 0 Cand and perfuse for 15 seconds.
Switch the perfusate to the Ca2+-buffer and allow perfusion for 15 seconds.
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