A cross-sectional survey of Canadian CHD patients identified fears relating to self-cannulation, perceived lack of efficacy in performing dialysis, burden on family members and fear of a catastrophic event while dialyzing at home as important barriers to the widespread adoption of NHHD [ 5].
We performed a burden analysis collapsing all rare variants with an MAF <0.01 across the whole protein.
To determine colonization ability, we performed fungal burden analysis in the lungs and brains of animals infected with wild type and cna1Δ mutants.
A second approach is the variable threshold (VT) test, which performs a burden test for variants with minor allele frequencies (MAFs) below a certain threshold and minimizes the P-value over the observed MAF thresholds (Lin and Tang, 2011; Price et al., 2010).
In some countries with the highest viral burden, performing these assays is currently impractical.
To perform a burden-based procedure, we simply set, and force for all r.
For a union of k markers, the union test is approximately k-1 times faster than the corresponding single marker test, because the computational burden of taking the union is less than the computational burden of performing one Fisher's exact test.
Because it is well known that each individual carries a burden of rare coding mutations, we sought to establish whether there is a similar gene expression burden by performing gene-specific one-way ANOVA contrasting each individual's three pseudo-biological replicates against those of the other 11 individuals.
Alteon's gear splits up requests for Internet information among a company's individual servers, allowing the servers to perform at their best, and can spare those servers the electronic burden of performing routine tasks like encryption.
Declining ratings prompted sponsor Procter & Gamble to cancel his show in the spring of 1953, with Skelton announcing that any future television shows of his would be variety shows, where he would not have the almost constant burden of performing.
