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To estimate mutation-induced structural changes, we performed structure remodeling for LATS1/2 based on two AGC family proteins, ROCK and PKC.
It can also be observed that the number of performed structure function evaluations FE increases significantly with the increase in the level of SN redundancy as a direct result of the exponential increase in |Π 1|.
In order to compare the above classifier with an established alternative system of ancestry assessment we performed STRUCTURE analysis [22] of the 96 training set samples and the seven case samples.
We performed STRUCTURE analysis on a set of genome-wide SNP genotypes from the combined HGDP-CEPH and HapMap panels using 5,254 SNPs [18] that were located ≥0.5 Mb apart and thus expected to show little LD.
To performed STRUCTURE analysis [66], we assessed number of population groups (K), performing 10 runs at each K, from 2 to 8. The estimation of loge probability of the data using the F model favored the assumption of K = 7. Figure 9 shows results at different K values.
CMF and VL performed STRUCTURE and PCO analyses.
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To further verify structural distribution of nsSNPs in functional kinase regions, we also performed structure-informed multiple alignment of kinase sequences using PROMALS3D approach [129].
We performed structure-based virtual screening targeting the RORγ ligand-binding domain.
In this study, we performed structure-based pharmacophore model of the Dvl PDZ domain to discover novel small-molecule binders and identified eight compounds with micromolar affinity.
In this study, we performed structure-based virtual screening in combination with chemical synthesis and bioassay and discovered a class of small-molecule SMS inhibitors.
139 (2013) 124906), where they performed structure-based coarse graining of homopolymer melts using the polymer reference interaction site model theory, directly contradicts the well-established and widely cited finding by several research groups.
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