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These proposed structures have been experimentally performed, probing an enhancement of almost an order of magnitude in the Q-factor in respect with the basic case.
Then, an unpaired Mann Whitney test was performed probe by probe.
TF performed probe selection, microarray experiments and data analysis.
GEV and DSJ performed probe labelling, FISH and chromosome identification.
BMS performed probe preparation, hybridisations, microscopy and data analysis and prepared the manuscript.
To localise miRNA activity within the oesophageal mucosa in-situ hybridisation was performed, probing against miRNAs elevated in ulcerative oesophagitis.
This enzyme was chosen because significant work had already been performed probing the active site with different inhibitors.
RvD performed probe development, participated in the design of the study, optimized the described method, performed data acquisition, data analysis and data interpretation and drafted the manuscript.
The r2 value of the technical replica experiment performed probing two separate bead-arrays with the same RNA sample was 0.9876.
We then performed probe type bias adjustment beginning with QN or raw data and using beta-mixture quantile normalization (BMIQ) on β-values.
This implies that we have identified a true set of poorly performing probes.
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