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Therefore, we performed nearest neighbour matching both with and without replacement [ 43].
First, a spatial clustering was performed (nearest neighbour hierarchical clustering, (Everitt, Landau, & Leese, 1993)) and the locations within the clusters were selected.
We also performed nearest centroid classification for the intrinsic subgroups of FBC using the genes from Hu et al. on the MBC samples in our study as well as the MBC validation samples [ 21].
We then performed nearest neighbor matching of the two groups at a 1 1 fixed ratio, using a caliper width of 0.2 of the standard deviation of the logit of the propensity score.
Lastly, to explore the representation of the molecular basal-like BC subtype within this BC cell line set, we performed nearest centroid classification using the class centroids from Parker et al. [ 26], Sorlie et al. [ 27], Hu et al. [ 28], Prat et al. [ 8] and Guedj et al., [ 10] (referred to as PAM50, Sorlie500, Hu306, Claudin.Low and CIT256 respectively, in Figure 2B).
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