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To provide more detail about the sensitivity of the CquiOR2 + CquiOR7 receptor, we performed concentration response analysis for indole and each of the compounds that yielded responses that were at least 20% of the response to indole.
To further investigate the effect of VPA on Notch-1 activity we performed concentration and time course experiments.
To verify the results from the expression-arrays and to investigate if the difference between NPSR1-A and -B signalling might depend on NPS concentration or dynamics, we performed concentration- and time-response experiments.
To determine if the inhibition of sporulation was dependent on the concentration of antibiotic, we performed concentration range assays on three isolates of different ribotype, including a ribotype 027 (CD386) and VPI 10463, a well-known high toxin-producing strain used in various studies including in vivo assays in animals [ 25, 26].
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We performed concentration-response curves and observed an increase in CFTR stability at higher drug concentrations (Supplementary Fig. S2) with dual mTOR inhibitors, AZD-8055/KU-0063794 Akt Akt inhibitors, MK-2206/AKT-VIII.
We performed concentration-response curves for ET-1 10-11 - 33 × 10-8 M), and the influence of oxygen and NO on the arteries was examined.
In the present study, we performed concentration-dependence curves to better compare the effects of these progestins over a wider range of concentrations on some of the investigated targets.
Furthermore, we study its robustness against noise on the receptor level and its ability to perform concentration invariant odor recognition.
The second objective was to perform concentration and photoactivation time dose-response studies.
Building on our observation that Enzalutamide reverses DHT-mediated AR thermal stabilisation, we used our newly established CETSA HT assay to perform concentration responses of AR antagonists in the presence of a fixed dose of DHT (1 nM) prior to heatshock at 46 °C.
Sand et al. (2012) provided a comprehensive review of the considerations for selecting appropriate standardized BMRs when performing concentration-response analysis of in vitro data.
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