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In order to assess the effect of the different approaches in preventing/halting disease progression, we performed comprehensive time-course analyses examining relevant pathological hallmarks.
We herein collected 345 samples from five different diseases and performed comprehensive analysis of 20 factors for the first time.
We performed comprehensive miRNA and mRNA profiling over a 7-point time course, encompassing all recognized stages of lung development beginning at embryonic day 12 and continuing to adulthood.
We also performed comprehensive expression analysis of the nine SLC17 genes using quantitative real-time PCR (RT-PCR) in the rat.
To obtain insight into the role of miRNAs in pathogenesis of biliary atresia, we performed comprehensive expression analyses of miRNAs and mRNA from EHBDs at the times of epithelial injury, lumenal obstruction, and atresia in the experimental mouse model.
All four performed comprehensive literature searches.
XL performed comprehensive statistical analysis of the data.
We performed comprehensive evaluations of different methods on various settings.
Despite the recent progress in fast and effective computational approaches, some of which were here reviewed, the major drawbacks is the experimental effort required to perform comprehensive phosphoproteomic time-course experiments.
The objective of this study was to perform a comprehensive time course analysis of the effect of T cell-specific deletion of PPAR γ on the development of experimental IBD by using a systems approach aimed at examining immune cell distribution, global colonic gene expression and gut immunopathology.
Here, we first performed a comprehensive quantitative real-time-PCR (qRT-PCR) analysis of subtilases to investigate their expression patterns in different tissues.
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