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(ii) There are marked differences in performance of signatures from individual data sets, possibly reflecting the quality of the data or the diversity of the analyzed patient cohorts.
These problems include poor overlap among discovered gene signatures, the unstable nature of gene expression signatures, and poor performance of signatures when applied to other datasets [ 7, 9- 11].
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In the orchestra's maturity, a performance of signature pieces seems to have an elegiac feeling, some players say.
Our experiments to measure the performance of signature generation were carried out in two ways, one in the secure zone and the other in the normal zone based on inter-domain communication (NZ communication agent and SZ communication agent).
Though Yusuf's performance of signature pop hits "Father and Son," "Wild World" and "Peace Train" was a highlight Thursday, it was a ceremony as noted for who wasn't there as who was.
Authors' response: So far we have compared the resulting prognostic signature to other two relevant signatures, showing the performance of our signature is comparable to that of these signatures.
Despite comparable prognostic performance of these signatures and high correlation values among them, we observed that these signatures generally retained their prognostic significance independent of each other when testing two signatures at a time in multivariate analyses (Table 3).
This reinforces our previous claim, the poor performance of the signatures on the "MCI" dataset is related to the fact that the signatures were not trained to identify between AD and MCI.
In spite of this fact, the overall performance of all signatures seems very robust.
The performance of the signatures was validated using a patient cohort of similar size (Duke University, n = 96).
The performance of optimized signatures was validated by "leave-one-out" cross validation within the training set firstly, then with the validation set [14].
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