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Wackerhage prepared an academic paper earlier this year highlighting experiments that had produced enhanced physical performance in mice and rats, and the possibilities offered by gene doping and screening for enhanced athletic performance.
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Moreover, resveratrol, a known polyphenol considered a mimetic of CR, also induces changes in muscle mitochondrial activity and improves physical performance in mice [19], [20] and could be considered as an ergogenic factor able to modify muscle physiology [21].
Given the widespread use of static nose-poke devices for testing operant performance in mice, we therefore designed and fabricated a retractable nose-poke device.
Indeed, this appears to be the case with the recent success of early clinical trials of oral L-serine supplementation that reduced deoxy-SL levels in serum and also led to an improvement in motor and sensory performance in mice [ 50].
There was no direct correlation between in vivo peptide stability and analogue performance in mice.
Further, the 2,4-DNT induced antagonism of PPARα signaling acted as the principal MIE for impaired energy metabolism that led to adverse outcomes of reduced body weights and diminished exercise performance in mice.
However, 8-day repeat dosing at 1 mg/kg did not improve Y maze performance in TgAPP mice, and actually impaired Y maze performance in wild-type mice.
Retractable levers did not support sufficiently high and stable levels of performance in mice.
Our study found that Ferreira's aerobic training protocol [ 12] was able to improve performance in mice without leading to DNA damage in peripheral blood and skeletal muscle cells.
Guanfacine has been shown to improve spatial working memory performance in mice [ 64], rats [ 65], monkeys [ 55, 66] and humans [ 67].
High protein content, leucine and fish oil reduce improves functional performance in mice with cancer cachexia highlighting the relevance of dietary supplementation for cachexia [ 41].
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