In theory, the enhanced activity of cytokine combinations compared to single cytokines could reflect either (a) different cytokines stimulating distinct subpopulations of T cells, or (b) cytokines acting synergistically to induce single T cells to perform multiple functions (i.e., induction of polyfunctional T cells).
The nanoclays synergistically improve how the metal hydroxide retardants perform, Gilman says.
In the transcriptome-profiling study performed to identify genes synergistically up-regulated by IFN-γ and TNF in macrophages, several proinflammatory cytokines and also TLR agonists were reported to stimulate increased expression of newly identified immunoresponsive gene 1 (IRG1) transcript [ 27].
To determine whether I3C and bortezomib interact synergistically, isobologram analysis was performed.
Heterologous expression in Xenopus oocytes was performed to finally show that OST1 and CPKs synergistically activate SLAC1 by phosphorylation.
To further understand the role of the metabolic syndrome as a risk factor for the onset of depressive symptoms, we performed analyses to explore whether its components act synergistically by testing interactions among them.
To understand whether low concentrations of MMRi64 and Nutlin3a will synergistically inhibit cell growth by apoptosis, we performed combination experiments with the two compounds in NALM6 cells.
Three-factor analysis was performed to evaluate whether the demethylation of FLT1 or KDR synergistically enhanced the effects of sunitinib or axitinib treatment in four RCC lines with different FLT1 and/or KDR methylation statuses.
The present study was performed to investigate the capability of gemcitabine and pemetrexed to synergistically interact with respect to cytotoxicity and apoptosis in T24 and J82 bladder cancer cells, and to establish a correlation between drug activity and gene expression of selected genes in tumour samples.
Alpert et al. also suggested that different cardiac biomarkers, when performed simultaneously on patients with chest pain in the ED, may act synergistically and have a better diagnostic performance when used in combination than when interpreted individually.
This observation suggested that the NAC synergistically improved 24-hour retention since the MINO plus NAC group performed better than MINO group despite no effect of NAC (post-hoc, p<0.01).
