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With the updated estimates of the FDRs and FNRs for each protein, we perform stringent tests to identify protein characteristics that correlate with elevated or reduced FDRs and protein degrees.
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The crux of the complaint is the willful failure of Bear Stearns to assess the quality of the loans it was packaging into securities, though it assured investors it was performing stringent due diligence.
Due to these computational limitations, we performed stringent analyses by Bayesian testing of alternate topologies on the former dataset, represented in Figure 2 and Table 1 (see below).
We performed stringent, uniform QC procedures on the resulting data.
We performed stringent quality controls of all expression arrays by reconstructing the hybridization images.
We again performed stringent quality controls and removed all patient or reference samples where expression or copy number microarrays had hybridization artifacts.
As ORC has not been found previously to interact with any member of the Hat1p complex, we performed stringent reciprocal affinity tagging and purification experiments using C-terminally TAP-tagged versiofs ORCORC subunits (Orc1p-6p).
Second, we excluded any remaining transcripts with conserved protein coding potential, including the potential to produce small peptides, by performing stringent codon-substitution frequency (CSF) analysis (Lin et al., 2011).
We then performed stringent quality control for 666 target gene by which we selected only high coverage genes that were sequenced coding-region based on the public database (db).
The miRDeep algorithm performed stringent searches based on the miRNA biogenesis model [ 43] and produced information on miRNA conservation, thermodynamic stability, ability to form a hairpin with the shape and sequence of the pre-miRNA molecule, number of sequences that matched mature miRNA sequences and number of sequences that matched star sequences.
In order to perform a stringent evaluation, we conducted a k-fold cross validation test.
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