All the authors of the article undersigned have significantly contributed to its development: LCA and CEP have collected the sample and made the database, as well as they collaborated in the theoretical foundation; CBM and LRF performed statistical analyzes, interpretation of results and collaborative discussion.
JL performed statistical analyzes.
IG conceived and organized the study, participated in patients' inclusion and follow-up, performed statistical analyses, analyzed results and wrote the manuscript.
JG co-drafted the manuscript, performed primary cell culture experiments, ROS assays, animal dissections, tumor measurements and performed statistical analyses, and analyzed and interpreted the results.
ACM, PS, PMH, designed the experiment, interpreted the results and wrote the manuscript; PS scored the phenotypes; PS and TF performed re-sequencing; ACM and PS performed statistical analyses; TJC analyzed the SNP genotype data; GM and KS provided insightful interpretations of key results.
D. K. evaluated patients, analyzed data, performed statistical analyses, edited manuscript.
RS analyzed data, performed statistical analyses, and helped draft the manuscript.
JTN designed and performed the research, collected the clinical data, analyzed data, performed statistical analyses and wrote the paper.
RYW carried out the transcriptome and qRT-PCR studies, participated in the behavioral experiments, analyzed and performed statistical analyses on all data, participated in the design of the experiment, and drafted the manuscript.
DDD carried out all mRNA and protein expression experiments (unless otherwise noted), scored IHC samples, analyzed data, performed statistical analyses (except for survival and regression analyses) and drafted the manuscript.
