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This offers very useful tools to perform proof of principle experiments to determine the role of specific genes and potential new therapies.
Since the results of this experiment strongly suggested that Treg inhibit innate immune responses, we decided to perform proof of principle experiments using B16FasL to address this point.
PET can examine sensitive molecular processes without perturbing them, so as novel radiotracers become available to study proliferation, apoptosis, angiogenesis and hypoxia, it will be possible to perform proof of concept pharmacodynamic studies to ascertain whether an agent is modulating tumour biology.
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By building on basic science discoveries in the academic setting, applied science can perform proof-of-concept work with simple, benchtop experiments.
Pharmacological properties of the Nutlins allowed the compounds to achieve adequate exposure levels in mouse plasma through the desirable oral route of administration and permitted us to perform proof-of-concept studies using mouse xenograft models of human cancer.
As illustrated in the translational research map in Fig. 1, optical medical imaging devices are initially developed in basic research fields, mostly in academia, in order to perform proof-of-principle experiments, designing prototypes for conceptualization of the imaging capability, and testing the feasibility of the measurement concepts.
Representative designs from each technique are used for performing proof of concept electrical simulations.
We suggest that complex continuing care institutions consider performing proof of concept trials to investigate the use of PGx.
So far, it has performed proof-of-concept demonstrations in Venezuela and Panama, and is preparing for more in Mexico, Canada, Argentina and America.Another new type of concrete is at an even earlier stage.
Finally, we performed proof-of-concept experiments that demonstrate that the presented system opens new avenues to use the developed 3D model of the bone marrow niche for drug screening and toxicity testing, in particular for myelotoxic effects of chemotherapeutics.
He reported on a recently performed proof-of-principle study that tested the power of applying MALDI-MSI to demonstrate the qualitative drug distribution of inhaled bronchodilators in COPD patients.
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CEO of Professional Science Editing for Scientists @ prosciediting.com