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Nevertheless, a baseline compliance of 21% is unacceptable and raises the inevitable question as to why highly educated and trained healthcare workers perform HR so rarely.
BRCA1 is then essential in order to recruit repair effector proteins, including Rad51, that perform HR through sister chromatid exchange [ 24, 25].
Interestingly, acquired resistance to PARP inhibitors in cells with BRCA2 loss-of-function alterations may result from late 'reverting' mutations, that is new deletions in the context of the BRCA2 gene that restore the normal open reading frame abrogated by the original genetic lesion, thus rendering the cells once again capable to perform HR (Edwards et al, 2008; Sakai et al, 2008).
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This knowledge prompted us to perform hr-HPV testing after 1 year from the initial assessment for cytological abnormalities.
As we did not perform HR-HPV testing before the second LEEP and before hysterectomy in these two groups, we were unable to compare HPV load before and after the initial LEEP treatment.
Our research (see our book HR Competencies by Ulrich, Brockbank, Johnson, Sandholtz and Younger) demonstrates that the most important competency of high performing HR professionals and leaders is that they operate as credible activists, not just as "pairs of hands".
We measured TMT HR experience by the accumulated years that the top executive team members, excluding the CHRO, had performing HR functions.
High performing HR business partners don't just react.
These observations speak in favor of centrally performed HR tests in general, but this cannot be applied to each individual.
BS performed HR MAS MRS and microarray experiments, did the preprocessing of the HR MAS MRS data, contributed to analysis and interpretation of HR MAS MRS and microarray data and drafting of the manuscript.
Before performing Hr-Hybrid Capture 2 (HC200 200 μl aliquots were stored at −80°C.
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