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Compound 30 which showed the most potent dual topo I and topo IIα inhibition with strong antiproliferative activity in T47D cell line was selected to perform further study on the mechanism of action, which revealed that compound 30 functions as a potent DNA non-intercalative catalytic topo I and IIα dual inhibitor.
Thus, it would be required to perform further study, such as that using immunoelectron microscopy and that assessing blood-testis barrier permeability.
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This indicated a need to perform further studies on the accuracy of the CAN fuel rate message.
The nine newly developed polymorphic markers recognise a sufficient number of varying loci to perform further studies on the conservation and breeding of this medicinal cultivar.
Based on the aforementioned results, we plan to perform further studies to address issues.
Consequently, it seems important to perform further studies on the potential protector effect of hyperoxia against IPE, in particular among SCUBA divers.
However, he's not ready to change how he treats prostate cancer patients until researchers perform further studies that confirm the effects of testosterone and clarify the treatment's risks.
Although further improvement of imaging technique is therefore necessary to assess whether biokinetics in metastatic bone tissue is similar between Radium and HMDP, the correlation of SPECT-derived uptake values we found in this study would encourage us to perform further studies on quantitative Ra-223 SPECT.
Based on the results from this study and the functions during the gene expression, we think that differences in methylation levels and patterns may be important to regulate tissue-specific gene expression and cell differentiation, however we need to perform further studies to confirm this.
We should perform further studies, preferably using a greater number of patients with glucose intolerance.
Thus, it is imperative to perform further studies for confirmation of autoantigen identification.
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