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A simple two-step subranging ADC architecture is used as an extra ADC in order to extract the data points of the stage-under-calibration and perform correction process without imposing any changes on the main ADC architecture which is the main trend of the current work.
Note that, as expected from the extent of LD, multivariate analyses using the SMARTPCA software package [42] which allows to perform correction for the extent of LD (by replacing individual SNP values with the residuals from a multivariate regression without intercept on the two preceding SNPs on the map, provided they are less than 200 kb apart) lead to almost identical results.
In this study we did not perform correction for multiple comparisons.
The stratified analysis was used to perform correction for the match-paired strategy.
Note that, since the multiple hypotheses being tested here are compared and ranked against each other (as opposed to accepting/rejecting individual hypotheses), it is not necessary to perform correction for multiple hypothesis testing.
We did not perform correction for excess medication purchase of calcium carbonate and activated vitamin D analogs (alfacalcidol) since there were frequent changes in doctors' orders for these drugs, often on a monthly basis.
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Therefore, we had to perform corrections for multiple comparisons in order to avoid Type 1 error.
Due to the exploratory nature of this study, we did not perform corrections for multiple comparisons.
Since this haplotype investigation was also exploratory in nature, we chose to not perform corrections for multiple comparisons.
For the final correction in all treated cases, we used TIBAX or CLUBAX device, which is a simple instrument to perform corrections in all three planes.
We performed correction of raw reads for the A. halleri ssp.
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