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To perform a value-based medicine analysis of clinical trials that evaluate the interventions of laser photocoagulation, intravitreal pegaptanib therapy, and photodynamic therapy (PDT) with verteporfin for the treatment of classic subfoveal choroidal neovascularization.
The paper performed a "value added" statistical analysis, which is a controversial measure that has been embraced by the Obama administration and some in the education community.
To assess whether the remaining uncertainty justifies future research, we performed a value of information analysis.
Because some variables (n = 7) had missing values, we performed a missing value analysis.
This is done by performing a singular value decomposition (SVD) on the matrix of data, with each column representing a variable and each row representing a multivariate sample.
One-way statistical analysis of variance (ANOVA) followed by post hoc comparison test (Turkey test) was performed; a P value <0.001 was considered significant.
We first performed a singular value decomposition (SVD) of the transcriptome data to evaluate the quality of the microarray experiments (Figure 2A).
Since multiple testing was performed, a p value of less than 0.01 was considered significant.
Because of the large numbers of statistical tests performed, a p value <0.001 was considered significant.
Spectral clustering (SPEC; Kluger et al., 2003 ) performs a singular value decomposition of the data matrix after normalization.
We also performed a singular value decomposition (SVD) [ 23] analysis of the correlation matrix for all 66 samples.
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