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Moreover, since the intention of this study was not to perform a hypothesis test advanced statistical analysis methods were not used.
The best way to determine which explanation is most likely is to calculate a confidence interval for the mean and to perform a hypothesis test.
As we did not perform a hypothesis testing regression analysis we assume that it was suitable for development of our clinical risk score.
The upper bounds are constructed as in the following expressions: (11) (12) One can also adopt the TI defined in expressions (10), (11) or (12) to perform a hypothesis test if the interest is to ensure that at least p-percent of the absolute differences between paired measurements are less than a predetermined constant κ0.
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It is important to emphasize that, although genome-wide SNP data have been collected for this sample, we did not perform a hypothesis-free genome-wide association scan for our measure of interest.
On an a priori basis, we elected to perform a hypothesis-testing meta-analysis that excluded the initial observations from WOSCOPS as well as an analysis of all available data including the hypothesis-generating WOSCOPS data.
Because of the low frequency of DMARD-free sustained remission (reflecting loss of disease persistence) and because of the lack of multiple large cohorts with data on this disease outcome, we were not able to perform a hypothesis-free genome-wide association study or to analyze the whole Immunochip.
The presence of an aftereffect was tested statistically by performing a hypothesis test with α = 0.05.
Similar to performing a hypothesis test, a 95% confidence interval that does not overlap another reflects a statistically significant difference.
In case of the statistical formulation of MRA [ 16, 17], the above objective can be achieved by performing a hypothesis test such as Z-test [ 21] on the distribution of r i j to determine whether the mean value of r i j is significantly different from zero.
This work used whole exome capture and massively parallel DNA sequencing to study targeted candidate mutations in selected genes, as well as performing a "hypothesis-free" analysis where we aimed to identify potential driver mutations by identifying variants with increased proportion of mutant alleles.
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