Exact(4)
Moreover, damping spectra corroborate these findings when hollows perfectly bind tightly the target analytes.
In plants, most miRNAs can perfectly or almost perfectly bind to their target mRNAs.
To promote exon definition, U1 snRNP does not necessarily have to perfectly bind at the 5′ss.
The first setting (P-value cutoff of 0.05, minimum free energy cutoff of -20.0 kcal/mol, maximum internal and bulge loop size of 1) was termed "hybrid11"; if maximum internal and bulge loop size was 2 but the seed region of miRNA could perfectly bind to 3'UTR of a gene (helix constraint of 2.7), we also considered this gene to be a potential miRNA-targeted gene (this setting was termed "hybridf22").
Similar(55)
"The perfectly bound, coquettishly trussed bird reminds me of a '50s debutante at a cotillion, not a hair out of place," he writes of a Thanksgiving turkey; "untrussed, it looks like a ravished slut, disheveled and eager for more".
For years, I thought trussing was a matter of aesthetics: the perfectly bound, coquettishly trussed bird reminded me of a 50's debutante at a cotillion, not a hair out of place; untrussed, it looked like a ravished hooker, disheveled and eager for more.
Clothing speaks in its own way, and a well-tailored outfit that fits you perfectly is bound to have people notice you.
Most plant miRNAs bind perfectly or nearly perfectly to complementary sites on their target genes.
However, using the settings, the predicted binding sites of targets can bind perfectly to miRNA, and the target sites belong mainly to the three categories of known miRNA target sites classified by Sethupathy et al. (2006)[ 49] [see Additional file 3].
They float about, awaiting a microbial encounter, then attach themselves to their preferred targets using a remarkable array of equipment — arms like grappling hooks, tails like hypodermic needles, fibres like teeth — each of which is perfectly adapted to bind to, and then sneak genetic material through, the bacterial membrane.
Rockefeller University researcher Jeffrey Ravetch has shown that antibody drugs like Herceptin no longer work well in lab mice when the portion of the antibody that flags the immune system is damaged even through they still bind perfectly well to the tumor.
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Justyna Jupowicz-Kozak
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