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Pain relief using sub-perception stimulation was not significantly different from sham stimulation (P = 0.96).
Three settings were delivered in a randomized fashion (1 1 1): full stimulation (i.e. customized stimulation parameters established during the therapy titration period), sub-perception stimulation, and sham stimulation.
Acute rescue medication was used in 31% of cluster headache attacks in patients receiving full stimulation, compared to 77.4% treated with sham stimulation (P < 0.0001) and 78.4% with sub-perception stimulation (P < 0.0001).
Pain relief at 15 minutes using sub-perception stimulation (7.3%) was not significantly different from sham stimulation (7.4%) (p = 0.96).
Pain relief response per patient is shown in Table 5 for full stimulation and sham stimulation only; data from sub-perception stimulation are not shown.
Mean intensity was 1.6 ± 0.8 mA (range: 0.6 3.9) during full stimulation, contrasting with 0.5 ± 0.3 mA (range: 0.1 1.4) during sub-perception stimulation.
Acute rescue medications were used in 31.0% of CH attacks treated with full stimulation compared to 77.4% of CH attacks treated with sham stimulation (p < 0.0001) and 78.4% with sub-perception stimulation (p < 0.0001 when compared to full stimulation, p < 0.68 when compared to sham stimulation).
The study employed a random insertion of placebo (27) that used three stimulation doses randomly applied when treatment was initiated by the patient for a CH attack treated during the experimental period: full stimulation (i.e. customized stimulation parameters established during the therapy titration period), sub-perception stimulation, and sham stimulation.
Organization by proximity may not seem to reveal anything more than a close correspondence between perception and stimulation.
Similarly, Lukac found himself startled by how the element of vibration changed his perception of stimulation.
Within the field of neurobiology, there are many subdisciplines that are concerned with the relations between mental and physical states and processes: Sensory neurophysiology investigates the relation between the processes of perception and stimulation.
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