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Despite this apparent similarity in survival, a great difference was evident in the capacity of both products to sterilize the thighs of survivors after 4 days of treatment: 100% mice in the innovator group had sterile thighs, while 0% achieved this goal after generic treatment, leaving approximately 4 log10 CFU of P. aeruginosa per thigh.
Inequivalent generics were not only incapable of sterilizing (detection limit, 100 CFU/thigh) the site of infection after 4 days of treatment at the dose required for maximal efficacy, but left 100,000 bacterial cells per thigh that disseminated effectively to the lungs (8-fold compared with the innovator).
Radiesse was injected according to predesigned vector maps (3 mL per thigh, 1.5 mL per hemiabdomen or brachial zone).
In all, 3 mL Radiesse solution was administered per thigh, 1.5 mL per hemiabdomen, and 1.5 mL per brachial zone.
As stated above, the extracorporeal shock wave therapy was applied in both groups (intervention and control group) with an identical number of impulses (2000 per thigh) and the same frequency (4 Hz), thus the time of the procedure was identical.
Treatment consisted of 12 sessions at intervals of 3 4 days, treatment of the skin of the lateral left and right thigh with 4,000 impulses per thigh per treatment session, homogeneously distributed over an area of 160 cm per side with an energy flux density of 0.018 mJ/mm.
Similar(54)
With two outs in the fourth, the Mets recorded their first hit off Zito in loud fashion when Bay crushed a 76-mile-per-hour, thigh-high changeup into the left-field seats.
To keep the total acquisition time reasonable, signal quantification was only achieved at one image slab level per leg (distal thigh) by using a dual turbo spin echo sequence.
Turnover experiments performed with l-[U-C]-tyrosine and S-adenosyl l-[methyl-C]-methionine showed the concurrent consumption of these molecules, and ∼1 equiv of 4-methyl-5- β-hydroxyethyl) thiazole phosphate was formed per mole of ThiGH.
The declines in Vopt (3.5 6.6% per decade) and lean thigh volume (LTV) or quadriceps volume (3 5% per decade) confirm that the decline in Pmax is the consequence of a decrease in the fraction of the cross-sectional area corresponding to fast muscle fibers in addition to a decrease in muscle volume.
where vr is the relative velocity in thigh height per second, and ht is the thigh height.
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