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Table 1 shows the median number of recorded dementia diagnoses per PCT, the mean proportion of dementia diagnosed per PCT and change in the mean number diagnosed per PCT compared with the previous year, from 2006 to 2012.

In the centres where CAs are developed, all CA participants will be selected with a maximum of 10 people per PCT.

Using an intracluster correlation coefficient of 0.05 [ 41- 43], and based on an average of 25 pregnant women per PCT, the design effect is 2.2.

The total number of CRH beds per PCT ranged from 18 to 82, and the number of CRH beds available per 10 000 older adults ranged from 4 to 20 (see online data supplement, table A).

We found that the mean number of dementia diagnoses per PCT per year (as reflected in GP recording of the diagnosis on their QOF register) and dementia diagnosis rate increased from the year the NDS was launched.

After adjustment for clustering by primary care trust (PCT), assuming an intracluster correlation coefficient of 0.01, and that five pharmacies per PCT would be recruited, 28 pharmacies per group were required.

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In our hospital, cost amounted to 14 Euros per PCT-test.

PCT kinetics over 72 hours were strongly associated with ICU and in-hospital mortality (adjusted OR [95%CI] per 10% PCT increase 1.3 [1.1 to 1.5], P = 0.001 and 1.3 [1.1 to 1.4], P = 0.001, respectively) (Table 2).

For the London Boost sample, 202 PSUs were selected at the first stage with unequal probability to ensure 6 PSUs were selected per London PCT (more in boroughs that had commissioned larger boosts).

Thus, it will be necessary to interview 900 professionals (300 per group) from 172 PCT (86 per group).

In the per-protocol analysis, PCT-guided therapy not only resulted in significant decreases in duration of antibiotic use, but a 2-day shorter ICU stay.

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