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The uncertainty in diagnostic clinical practice also contributed to uncertainty regarding the per examination costs of the economics (Table 2).
However, for VibraTip™, the sponsor calculated the per examination cost according to its battery life, irrespective of simulated clinical use.
The EAC considered that this was likely to be an overestimate and therefore the per examination costs would likely be higher.
The EAC further considered the per examination costs used by the sponsor for each device, which were the sole drivers of costs reported in the base-case analysis.
The sponsor estimated the per examination cost would be 0.2 pence, based on 5000 clinical examinations before battery discharge made the device unreliable.
For its calculation of the per examination costs for the 10 g monofilament and the 128 Hz tuning fork, the sponsor used estimates based on simulated clinic use and expected useful life (assumed to be 1 year), and had estimated these costs were 1.0 and 0.8 pence, respectively.
Moreover, the mean skin doses with the multidetector CT were 458 mSv per examination, whereas the doses with the 3DX were 1.19 mSv per examination.
Similar(4)
Pooled sensitivity and specificity, positive and negative predictive values (PPV and NPV), accuracy, and area under the summary ROC curve (AUC) of F-FDG-PET or PET/CT on a per examination-based analysis were calculated.
The specificity of F-FDG-PET or PET/CT in the postchemotherapy management of patients with seminoma calculated on a per examination-based analysis ranged from 47%to100%0%, with pooled estimate of 86%9595% CI: 81 89%).
The sensitivity of F-FDG-PET or PET/CT in the postchemotherapy management of patients with seminoma calculated on a per examination-based analysis ranged from 0%to100%0%, with pooled estimate of 78%95%5% CI: 67 87%).
For each study the number of true-positive, false-positive, true-negative, and false-negative findings for F-FDG-PET or PET/CT was recorded on a per examination-based analysis considering the qualitative PET analysis (visual analysis) performed by the authors.
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