To circumvent some of its limitations, such as tissue penetration, efforts have been made to reengineer the virus (Muzyczka & Warrington, 2005; Mitchell et al, 2010; Bartel et al, 2011; Yang et al, 2011; Kienle et al, 2012), notably generating an AAV variant capable of reaching the outer nuclear layer from the vitreous (Dalkara et al, 2013).
In order to clarify the factors that affect the BBB penetration, further efforts are needed to investigate the mechanistic nature of the BBB, and, as pointed out by Goodwin and Clark [ 7], the most fundamental need is for more high quality data, both in vivo and in vitro, upon which the next generation of predictive model can be built.
The foliage penetration measurement effort began in August 2005 and continued through December 2005.
What if the underground railroad had been constantly under efforts of penetration by the United States government on behalf of slavery?
But they argue that the increase has taken place nationally, reflecting a change in legislation in 2009 to broaden the definition of rape to include oral and anal penetration, as well as efforts to make it easier for women to file rape complaints.
"The important thing is that nothing substantially new has been learned in the last four years, and none of our efforts — informants, penetrations, planting of sensors — leads to a bomb".
"This could be a part of efforts against the penetration of western hostile forces".
The "Tibet Work Conference" predictably called for efforts to combat "penetration and sabotage" by Tibetan separatists.
Even though such membranes are needed, this should be complemented by scale-up and engineering efforts, to make penetration into the market possible, and to find creative engineered solutions based on hybrids and cascades, in which the separation of a single step can be enhanced.
This is an important prerequisite to many efforts to increase penetration depth and to better image extraction in OCT systems.
Because the Netherlands has one of the highest broadband penetrations in Europe, emerging research efforts in the areas of nanotechnology, life sciences, and other IT-related areas, and a new tax treaty, the country offers U.S. companies an important gateway into Europe.
