Sentence examples for penetrating sequence from inspiring English sources
Furthermore, DPT-APAF1 a bi-partite cell penetrating peptide containing APAF-1122 131 APAF-1122 131atinonsequence from Apenetratingin, linked to our previousequenceribed DPT-sh1 peptide shuttle, is also a PP1-interacting death molecule.
Within the last two decades several reports indicated that the C-terminus of HIV-1 Vpr is a cell penetrating sequence, a PP2A-dependent death domain and also displays toxicity against Gram-negative E. coli.
To develop new anti-HBV macromolecules that can cross the membrane barrier, we designed a series of artificial recombinant peptides including cell penetrating sequence oligoarginine R7 and several nucleocapsid binding subunits (NBS).
In addition, Taguchi et al., [25] identified a shorter sequence DTWPGVEALIRILQQLLFIH FRIGCQH corresponding to the residues 52 78 of the third α-helix domain of HIV-1 Vpr as a new cell penetrating sequence with transducing activity.
Together our data provide evidence for the first time that the Vpr77 92 sequence delineates a biological active domain of Vpr with PP2A1 binding and pro-apopototic capacities and, it is conceivable that this cell penetrating sequence may account for the Vpr internalization in uninfected cells.
A synthetic peptide corresponding to amino acids 1365 1399 of BRCA1-IRIS protein (see [ 32] for sequence) conjugated to cell and nuclear penetrating sequence was used.
It is well established that Tat peptides derived from the cell penetrating protein HIV-1 Tat are cell penetrating sequences that allow intracellular delivery of proteins.
The peptide is preceded by the cell-penetrating sequence, Antp.
The CPE-G4S-rGel construct was further engineered by replacing G4S with the furin-cleavable cell-penetrating sequence R9 to make CPE-R9-rGel.
Finally, we tested the effect of the cell-penetrating peptide containing only the consensus SH3 binding site (from amino acid 274 to 283 in Cx43) fused to the TAT-penetrating sequence, termed PEP-3.
GliNS2 cells were incubated with increasing concentrations of this peptide (50 100 μM), termed PEP-1, or with the TAT-penetrating sequence, used as control, for 24 or 48 h.
