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La acted as the penetration enhancer could accelerate the sintering of Mo Si O C ceramic coating and increase the penetrating capacity of the coating components into SiC coating.
Accordingly, TH-Lip could benefit from the unique property of TH, as the cell penetrating capacity of TH was concealed during the blood circulation and in normal tissues because of the neutral pH under those conditions.
Efforts are being made to use penetrating capacity of nanoparticles in biofilm studies [36, 37, 38].
Their potential for BBB penetrating capacity is also endorsed by their physico-chemical properties: they have a low molecular weight, a low number of rotatable bonds and few or no hydrogen bond donor/acceptor(s).
In this study we evaluated the cytotoxic potential of Ag-nps of varying sizes and surface conditions in HEK cells, their penetrating capacity into porcine skin after topical repetitive daily dosing for 2 weeks, and the localization of the Ag-nps within HEKs and porcine skin.
However, when TH-Lip reached the tumor, and as pH declined, histidines in TH peptide protonated and the surface charge of TH-Lip converted from negative to positive, initiating activated cell penetrating capacity and leading to enhanced cellular and tumor spheroid uptake.
Similar(54)
CIGB-552 is a peptide-based drug with antitumor effect and cell-penetrating capacity [ 4].
The first step was to prove that E9 could in fact mask the cell-penetrating capacity of the R9 in 2008 cells.
Such biological findings, in combination with the peptide cell-penetrating capacity, made L-2 an attractive lead molecule for further structural optimization.
But Helen always retained a capacity for penetrating observation and ironic comment on the mores of her adopted country.
The hallmark of this new generation of cell penetrating sequences is their capacity to evade late endosomal trapping and thus substantially enhancing both the intracellular delivery and the functionality of peptide drugs targeting intracellular ligands.
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