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Being a lipophilic compound with the presence of an unsaturated side chain, tocotrienols are able to penetrate efficiently into adipose tissue.
We found that NAO does not penetrate efficiently into intact mycelia.
A likely reason was that the stain did not penetrate efficiently into this part of the Env.
This may explain the promising pre-clinical and clinical results of the prodrug TPZ referred to in [ 10], despite previous modelling suggesting it does not penetrate efficiently into the tumour [ 15, 16].
In the same way, DNA molecules over 300 bp cannot penetrate efficiently through the nuclear envelope, which constitutes an obvious obstacle for foreign DNA uptake, either from natural origin or from human-developed technologies, such as cell transfection.
On the basis of our findings, we next developed a biodegradable polymeric nanoparticle platform and tested whether drug-loaded nanoparticles capable of rapid penetration within intracranial 9L glioma improve efficacy of a chemotherapeutic agent, as compared to otherwise similar nanoparticles that lack the ability to penetrate efficiently and as compared to unencapsulated drug.
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Design 2's performance proofed to be superior to Design 1's performance, because its lateral cavities are able to penetrate more efficiently into the solid body.
So, we expect the antisymmetric component of D0 and the symmetric components of DE2 and DE3 to penetrate more efficiently into the upper thermosphere.
C. glabrata lives mostly on mucosal surfaces and does not penetrate tissue efficiently.
FAM- PDP1 did not penetrate cells efficiently, and showed extra- and intracellular aggregation in different cell types at higher concentrations.
The results suggest that SW IV-52s does not penetrate cells efficiently during 24-h treatment and the sigma-2 moiety in SW III-123 delivers the SMC moiety into SKOV-3 cells effectively.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com