HELP microarray data has been submitted to the GEO database for public access (accession number pending) Validation of HELP microarray findings was carried out by MALDI-TOF mass spectrometry using EpiTyper by MassArray (Sequenom, CA) on bisulfite-converted DNA as previously described[31].
Serum SPD is a promising lung-specific biomarker to track clinical health outcomes of patients with COPD, pending validation of these early findings with larger clinical studies.
Interestingly, nuclear localisation of B7-H3 strongly predicted poor outcome in colon cancer, suggesting that nuclear B7-H3 might be considered a new biomarker that could facilitate colon cancer treatment decisions, pending validation of the results in other CRC cohorts.
4) Characterization of enzymes that could be linked to posttranslational modification of teretoxins, pending validation by proteomic analyses of terebrid venom duct components.
A simple scoring system intended for clinical use was constructed and internally validated, pending validation in an independent cohort.
Attending to the "BIPED" (Burden of disease, Investigative, Prognostic, Efficacy of intervention and Diagnostic) biomarker classification [ 38], SOD2 could be considered as a diagnostic marker pending validation, and also a burden of disease marker since, as shown in this study, its serum levels are significantly different attending to the K/L score.
Preliminary analysis of the data also suggests the possibilities of ethnic group specific disease related polymorphisms, pending validation in future studies.
In summary, our results provide compelling evidence for the potential usefulness of serum MIC-1 as an additional noninvasive diagnostic and therapeutic monitoring marker in patients with PDAC, a concept that can be incorporated into routine clinical practice in the not-so-distant future pending validation in large-scale multicenter prospective trials.
Its broad mandate has been successfully achieved, only pending the validation of its accelerator with its conventional facilities.
But, pending further validation of this novel method, it may be a promising and cost-effective way to assess infection risks and to evaluate the effectiveness of salmonella control programmes across countries or over time.
To validate treatments tested in clinical trials, and to make the results of different studies comparable, it seems relevant to use a full geriatric assessment such as CGA, allowing fit patients to be separated from the vulnerable and fragile, pending prospective validation of geriatric screening tools (Luciani et al, 2010; Pal et al, 2010; Soubeyrand et al, 2011).
