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"It's the same old story," said Jerry Kaplan, an entrepreneur who help found the Go Corporation to build a pen computer in the late 1980's.
Data are entered manually by striking the keys of a keyboard, touching a computer screen, or writing by hand on a digital tablet or its variant, the so-called pen computer.
Then there is Mr. Campbell, a former chief executive of companies like Intuit; Go, a renowned but failed maker of a pen computer; and Claris, which made software for Macintosh computers.
Go was a pioneering pen computer company that attracted some of the technology industry's most famous executives, spent $75 million of the investors' money and ended up with little to show for it.
And while pen computing has finally gained a degree of acceptance with consumers through devices like the Palm line of personal digital assistants and tablet PCs, those remain niche products, not the general-purpose machines that some pen computer pioneers envisioned.
From the obtained images, areas within the biopsies occupied by bone, biomaterial and connective tissue were identified using a pen computer (Cintiq companion, Wacom, Düsseldorf, Germany), coloured (Photoshop, Adobe, San José, CA, USA) and digitally measured using an automated image-analysis system (CellSens, Olympus Corporation) (Fig. 5).
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Pen computers could find markets in education, architecture, graphic design and user-interface design, he said.
Its advantage is that it will work with existing Windows programs as well as any new ones written specifically for pen computers.
But pen computers like Microsoft's Tablet PC have had only lukewarm success, and writing notes on a palmtop requires learning a kind of shorthand.
"If they're actually claiming the innovation high ground, they're just not being observant of history," said Paul Mercer, a designer who worked on a variety of hand-held pen computers at Apple Computer in the early 1990's.
Go, a private company, is believed to be the front-runner with its Penpoint software, scheduled for delivery later this year and already endorsed by I.B.M. Penpoint is a completely new operating system designed for pen computers.
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CEO of Professional Science Editing for Scientists @ prosciediting.com