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PEEP chosen by the PEEP titration procedure (titrated PEEP); PEEP set at 4 cm of H2O (PEEP4).
Patients in each subgroup will be randomized to one of two ventilatory strategies during intraoperative period: (1) PEEP chosen by the PEEP titration procedure (titrated PEEP); (2) PEEP set at 4 cm of H2O (PEEP4).
During both ZEEP periods, if oxygen saturation as measured by pulse oximetry (SpO2) decreased below 92%, PEEP ventilation with the PEEP set at the initial value was resumed.
ETS+LR, endotracheal suctioning followed by a lung recruitment manoeuvre; ETS-LR, endotracheal suctioning without a following lung recruitment manoeuvre; FiO2, fractional inspired oxygen; set PEEP; set positive end-expiratory pressure; Intrinsic PEEP, PEEP above set PEEP after an expiratory hold; Vt, tidal volume.
The ventilator settings (inspiratory pressure, PEEP, set respiratory rate, FiO2, and inspiratory time) were kept unchanged and similar across all modes.
A trial of spontaneous unassisted breathing (SB) was performed in all subjects at the beginning of the study protocol (SBI), followed by three NIV trials with FM, HS, HN at baseline settings (PEEP and PS set at 5 cmH2O) and two additional trials with the increased settings (PS and PEEP set at 8 cmH2O) for HS and HN only.
Similar(11)
EIT PEEP setting.
PEEP setting in hypoxemic respiratory failure and ARDS remains controversial.
We describe the use of trans-pulmonary pressures (TPP) measurements for optimization of external PEEP setting.
TPP-guided PEEP setting was higher than indicated by the Express strategy in all but one patient.
Little is known about evaluation of PEEP setting based on end-expiratory transpulmonary pressure at zero flow (PEEPtotL) in PP.
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