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Oxidation of diaphragm protein at a molecular weight of 200 kDa (that is, myosin heavy chain oxidation) increased with CMV, with and without PEEP (data not shown), with concomitant suppression of IGF-1 mRNA [ 27], the gene responsible for protein synthesis via the Akt/mTOR signaling pathway [ 41].
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Table 1 Characteristic of included patients Patients (n) 30 Weight (kg) 80 ± 16 BMI (kg/m2) 29.8 ± 6.3 Gender (M/F) 15/15 Age (yr) 62 ± 14 SAPS II 62 (52 76) Dialysis, n 30 (100) Vasopressors, n 27 (90) Plateau pressure (cmH20) 20 (18 25) PEEP (cm H20) 3 (2–5) Data are expressed as mean ± standard deviation or median (first third quartile) according to distribution.
After the collection of data, the PEEP was decreased to 17 cmH2O and data were again collected as described above.
After curarization (pancuronium 1 mg/kg, i.v). the ventilation was started and ventilatory data (PIP, PEEP, Vt, minute volume, inspiratory and expiratory time) were continuously recorded until sacrifice with sodium pentobarbital (100 mg/kg, i.v ., after 10-minute ventilation.
Some of the above-mentioned parameters have been quantified using remote sensing and GIS data by peeping into the past and the present demonstrating sufficient practical and scientific value for the present work.
For subsequent statistical analysis, data for corresponding PEEP levels and identical time cues were averaged.
Essentially, the data obtained at PEEP 5 and 10 cm H2O were almost the same.
Respiratory data during the PEEP steps are presented in Table 2.
Fifty-seven patients completed the study (27 in the control group and 30 in the decremental PEEP titration group) and contributed data for the analyses.
After reaching steady-state conditions while rabbits were ventilated with a particular PEEP, a first set of data was collected and considered as baseline before RM.
ABG: arterial blood gas FiO2: fractions of inspired oxygen ICU: intensive care unit PaO2: partial arterial oxygen pressure PDMS: patient data management system PEEP: positive end-expiratory pressure SaO2: arterial oxygen saturation The authors declare that they have no competing interests.
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