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Figure 1 Pedigree structure.
Fig. 1 Pedigree structure.
The Pedigree RElationship Statistical Test (PREST) was used to verify the pedigree structure and detect relationship misspecification.
FBATs can apply any type of pedigree structure including missing parental data, multiple siblings, and extended pedigrees.
In the absence of linkage information, we can instead use a "genome-wide coverage" metric computed with the pedigree structure.
It is well known that failure to properly account for population or pedigree structure can lead to spurious association as well as reduced power.
In relationship testing the aim is to determine the most probable pedigree structure given genetic marker data for a set of persons.
We propose a method, ROADTRIPS, for case-control association testing in samples with partially or completely unknown population and pedigree structure.
The resulting pedigree structure from the parental assignment analysis is presented in Table 1.
The correct pedigree structure could not be identified from the data.
The original GRAMMAR relies on the availability of a precise and complete pedigree structure for heritablity estimation in step (a).
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