Sentence examples for pedigree design from inspiring English sources

Simulations were based on a general pedigree design originating from 2 unrelated sires.

Hence the high-risk pedigree design is advantageous for the detection of rare risk variants.

Four different designs were used: a pedigree design of unrelated full-sib pairs, a pedigree design with MZ and DZ twins pairs with a ratio of 1 2 MZ and DZ pairs, a within-family design using full-sib pairs, and a population design using nominally unrelated individuals.

An advantage of a pedigree design for gene identification is that a small number of cases and a well-delimited region can be easily defined and increases the efficiency of downstream experiments.

Although the derivations from Raffa and Thompson were for a pedigree design, they should also apply to other experimental designs, such as those where GRMs are estimated from marker data.

It can be estimated using pedigree designs and, more recently, using relationships estimated from markers.

At N = 10,000 the sampling variance of the population design approaches that of the pedigree designs, and at N = 100,000 it becomes the most powerful design.

Analogous to the within-family design, the sampling variance is inversely proportional to the square of the sample size, rather than by 1/ N in pedigree designs.

For pedigree designs, the sampling variance is inversely proportional to the variance of relationship in the pedigree and it is proportional to 1/ N, whereas for population samples it is approximately proportional to 1/ N, where N is the sample size.

Our tests show that when analyzing for rare variants, a pedigree-based design is more powerful than a population-based case control design.

We use two pedigree crossing designs to either maximise or minimise inbreeding on the X-chromosome whilst producing identical autosomal inbreeding.