Exact(1)
In the simulations using the observed pedigree, average accuracies of predicted breeding values for the log squared estimated residuals were in reasonable agreement with the expected values calculated according to formulas in [ 3], given the amount of information available and the values simulated for the heritability of residual variance (h²v).
Similar(59)
Similar to the heterogeneity of pedigree knowledge, average IBD coefficients (average C and F) ranged from 0.2% (C and F in Comtois horse breed) to 9.1% (C in the Barbet dog breed).
We investigated whether increased fragmentation within a matrilineal pedigree (lower average coefficient of relatedness among matriline members; absence of the matriarch) is associated with a greater number of communities per matrilineal grooming network, which may be an indication of instability within the matriline.
For EBV for selection at a later age, the improvement originated mostly from Mendelian sampling terms, probably because the pedigree parental average EBV were much more accurate than at the earlier age.
From Taihang we evaluated a kindred of 293 individuals with 32 affected members as well as four other large pedigrees; from Chaoshan we studied two large pedigrees whose average age of onset was 49.25 years.
The SNP-based and pedigree-based average coefficients of relationship were 0.34 and 0.19, respectively.
The pedigree-based average estimates of additive and nonadditive variance were 22%and25%5%, respectively (results not shown).
The minimal average pedigree depth of gametes is thus larger than the minimal average pedigree depth for 220 cells that are the only descendants of a primordial progenitor – i.e. log2(220) = 7.78 – and likely smaller than the minimal average pedigree depth for 3000 cells – i.e. log2 3000) = 11.55.
The 8 CRC cases in the linked pedigree had an average age at diagnosis of 61 years (P=0.06 compared with all cases); average survival of 191 months (P=0.24 compared with all cases); and 2/8 cases classified as overweight, obese, or morbidly obese (P=0.26 compared with the distribution for all cases).
We thus asked whether average pedigree depth of differentiated cells can be minimized to a value close to its theoretical minimum even with an MZ of limited size.
The minimal average pedigree depth of the ~3000 germ cells produced over the lifetime of a gonadal arm is log2 3000) = 11.55.
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