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A prospective study enrolled pediatric patients under five years of age presenting to the emergency room or the outpatient clinic at Abou El Reesh Hospital in Cairo over a one-year period.
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This is the first retrospective observational trial of antifungal prophylaxis after allogeneic HSCT that has been carried out with a large cohort of pediatric patients under eighteen.
120 pediatric patients under eighteen years of age with hemato-oncological malignancies, non-malignant hematological diseases, and inborn errors of metabolism undergoing allogeneic HSCT were included in this retrospective analysis.
The study is a single centre, retrospective survey on antimycotic prophylaxis in pediatric patients under eighteen years of age who underwent allogeneic HSCT between January 2006 and June 2010 at the University Children's Hospital Tübingen, Germany.
In total, 120 pediatric patients under the age of eighteen years, divided into two groups, were evaluated in this analysis.
There were 57 (11.5%) pediatric patients under the age of 19 years and 437 (88.5%) adults.
We excluded all pediatric patients under 18 years of age and adult patients who arrived at the ED to be seen directly by the specialist.
Antifungal prophylaxis shortly after transplantation is therefore indicated, but data for pediatric patients under 12 years of age are scarce.
All pediatric patients under the age of 18 and adults with allergy/intolerance to levofloxacin received ceftazidime for neutropenic prophylaxis.
Pediatric patients were recruited from five participating sites including an academic obesity clinic, three private pediatric practices and a federally qualified health center in North Carolina.
AST >1.5 and 2.5 times the normal value occurred in a total of seven pediatric patients in the fluconazole group, five pediatric patients in the itraconazole group, and six pediatric patients in the posaconazole group (Table 3).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com