High mutational rates in mtDNA have been associated with an inaccurate DNA repair system (Bogenhagen 1999 ), the absence of histone-like protein, and the peculiar mitochondrial replication model, characterized by single-strand intermediates, which was found to be a convincing explanation for strand mutational bias (Reyes et al. 1998 ).
It is unknown whether this type of transcriptional regulation may operate in the peculiar and varied replication schemes used by apicomplexan parasites to reproduce.
Subsequently, they formed PGCCs that used peculiar modes of replication to develop into a variety of stromal cells including erythroid cells, all conferring resistance to treatment with paclitaxel [ 71].
Because of the small number of DIRS1-like elements described to date, little is known about the distribution and the evolutionary dynamics of these retrotransposons, which differ to other TEs by their peculiar tyrosine recombinase -based replication model [ 41].
The peculiar distribution of the DNA replication machinery has led to suggestions not only of a cenancestor endowed with an RNA genome, but also of the polyphyletic origins of DNA and many of enzymes associated with DNA replication (Leipe et al. 1999; Koonin and Martin 2005) in which viruses may have played a central role (Forterre, 2006).
The peculiar kinetics of hepatitis C virus replication and T-cell induction soon after infection may have important implications also for the design of protective vaccines since memory responses may not be able to precede the early peak of viral replication.
We conclude that the inability of myotubes to complete DNA replication must be ascribed to peculiar features inherent in their TD state, rather than to the reactivation method.
Contrary to expectation, the first meiotic division is preceded by chromatid (DNA) replication and as a consequence two peculiar divisions (meiosis I and II) are required to halve chromosome numbers.
We observed the peculiar feature that the gene set with the highest MI (genes involved in DNA replication) was negatively correlated.
To explain this peculiar phenomenon, one can speculate that: i) early cell damage may occur already at initial stage of viral replication, when the viral load is still low; ii) immune-mediated reactions may play role [ 16].
