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The mitochondrial component of the genome is particularly interesting in bivalves because some species show a peculiar inheritance called "doubly uniparental" (DUI).
Some uncommon subgroups like late-onset autosomal dominant diabetes mellitus (LOADDM) may present peculiar inheritance patterns with a stronger familial component.
Although the possibility that MODY mutations have a causal role in this group is remote, the exclusion of the most common MODY mutations by sequencing the whole HNF1A and GCK genes is necessary given the peculiar inheritance and onset patterns.
A recent study by Kong et al. [ 24] found a region at 11p15 with a paternal inheritance associated with breast cancer, which further supports the possibility of allelic imprinting or a peculiar inheritance involving males with cancer and females developing breast cancer.
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This peculiar mtDNA inheritance pattern is known as Doubly Uniparental Inheritance (DUI; [ 4, 5]) or gender-associated inheritance [ 2, 3].
However, the generality of the proposed model is constrained because DUI is a peculiar mtDNA inheritance system that exists only in a few bivalve species.
The answer has been given by one of the authors: 'There is something peculiar about membrane inheritance.
We expand the number of the MKRN3 mutations associated with CPP and highlight the importance of an accurate family medical history to disclose the peculiar pattern of inheritance of this gene.
But it applies particularly strongly to ants (and also to bees and wasps), because they have a peculiar form of genetic inheritance in which females (and only females) share more genes with their sisters than with their daughters.
Given the peculiar features of mitochondrial inheritance, genetics and physiology, how transmission of viable mtDNA through generations is achieved is object of debate.
The detail and precision with which Carey has constructed the novel makes this wager seem not only possible but plausible, for Lucinda, known as the Glass Lady, bought herself a glass-works with her inheritance and the peculiar strengths and fragilities of glass as a substance is one of the things the novel is about.
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