These results strongly suggest that pathology-driven mechanisms underlie the peculiar HC engraftment, myeloid differentiation and turnover observed in the CNS of transplanted Twi mice.
This cancer is peculiar in its characteristics, exhibiting differentiation, maturation and metastatic transformation leading to poor prognosis and low survival rates among children.
One of the most down-regulated genes with cardiac expression was cdkn1c codifying for p57Kip2, a cyclin-dependent kinase inhibitor (CDKI), which showed a peculiar transcriptional regulation during cardiac differentiation, lost in the absence of sik1.
Enriched terms refer to peculiar biological role of each differentiation lineage.
Indeed, programme differentiation is a peculiar characteristic that can influence implementation but does not depend on programme actors, whereas exposure represents the amount of the programme delivered.
This peculiar mitochondrial phenotype is acquired during differentiation from myeloid precursors.
The model points to a peculiar role of cellular noise in differentiation and leads to non trivial predictions which could be subject to experimental testing.
They provide an optimal microenvironment for cell proliferation, migration and differentiation, due to their biocompatibility, biodegradability, peculiar structure and good mechanical properties.
The importance of this issue is also supported by a recent study showing that SDF-1α, by an autocrine/paracrine mechanism, regulates a peculiar set of the genetic program of macrophage differentiation.
Given the peculiar properties of stem cells, including their multilineage differentiation capability, it is of fundamental importance to understand the response of stem cells to senescence signaling, also in view of their high potential in regenerative medicine and cancer therapy.
