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We note that although vaccine deployment was after the peak, vaccination still has the potential to affect total numbers of ILI cases, and for completeness the vaccine planning component was included in all analyses.
We assumed identical vaccination rate trajectories for the medium and high intensity programs, although with greater peak vaccination rate gains by year 3.
Results show that if additional intervention strategies were not used to delay the time of pandemic peak, vaccination may not be able to considerably reduce the cumulative number of cases, even when the mass vaccination campaign is started as early as mid-October.
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We investigated the relationship between boosting interval and peak vaccine induced immune response, 1 week after vaccination.
Peak vaccine-induced anti-HBs level is directly related to antibody decay, as well as risk of infection and persistent carriage despite vaccination.
The ICER of the very high intensity program remained below < $100,000/QALY across all parameter ranges tested except when the peak influenza vaccination rate achieved in the high and very high intensity program was, respectively, >73.5% or <76.8%.
The peak responses to vaccination with MVA85A, in the UK and The Gambia, are the highest reported for any subunit vaccine in humans, at least using ELISPOT assays[22] [9].
However, for a January epidemic peak with high vaccination coverage, the attack rate-based strategy was more attractive than the outcome-based strategy, regardless of which endpoint was evaluated (Figure S2).
Blood samples for assessment of cell-mediated immune (CMI) responses were collected one month after the last vaccine dose in each vaccination schedule (peak response) and at month 19 of the study.
These analyses were adjusted for measurement time (between last vaccination and peak anti-HBs measurement) and vaccine group, which are known to affect peak anti-HBs [2], [17].
To examine the significance of the peak effect of the vaccination regimens at 1-week post-vaccination, statistical analysis of the cellular immune responses to PPD, antigen 85A protein and SPP was performed (BCG∶BCG n = 21 BCG∶MVA85A n = 14).
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