Exact(1)
We show by a combination of analysis and simulations that our model can, in a robust manner, reproduce the alternation of asynchronous phases, episodes of calcium peak synchronization and postexcitatory suppression.
Similar(59)
A histogram shows the summed activity of all neurons (as a field recording) except that each neuron composing a peak of synchronization can be identified.
The histogram of summed activity does not show significant peaks of synchronization in the control) but exhibits spontaneous and significant peaks of neuronal synchronization (network states in color) in the DA-depleted tissue.
A very useful feature of our model that may be difficult to obtain in such settings is the simple dependence of both the periods of the individual calcium peaks and synchronization events on the system parameters.
The main goal of this paper has been to design a model of coupled oscillators that could reproduce the experimental results of Terasawa [3] and in which we could identify the parameters controlling the most relevant features of the experimental observations, mainly the durations of the intervals separating the individual calcium peaks and synchronization events.
To exclude the possibility of accidental encounter of peaks (random synchronization) different cutoffs of synchronization were calculated for the control and treatment period of every coverslip.
Colors indicate neuronal column vectors or peaks of synchronization as indicated by the similarity index.
A similarity index was used to determine if these peaks of synchronization contained the same or different neurons.
The analysis of network states shows the similarity between peaks of synchronization and shows that microcircuit dynamics (with LLE) is basically dependent on the recurrence of the same dominant network state that absorbs most active neurons [ 3].
The second mean calcium peak of a synchronization doublet is thus higher than the first one.
It is clearly shown that there exists a correlation peak indicating the synchronization point.
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