When compared to tapering doses of methadone used for medically supervised withdrawal, peak withdrawal severity was worse with lofexidine, meaning people treated with lofexidine instead of methadone were more likely to have severe withdrawal, and reported higher peak scores for withdrawal symptoms.
Peak scoring: For comparison, I computed an operational index of SA as recommended by the Society for Psychophysiological Research (Boucsein et al., 2012), with a post-stimulus response window of 1 3 s (Barry, 1990; Boucsein, 2012; Dawson & Filion, 2007), and a post-onset peak window of 0.5 5 s (Boucsein, 2012).
There was a significant enrichment for OCT4 motifs for a peak score of 0.44 and above.
For a peak score of 0.33 and above, 15 of the 16 OCtargetgenesenes were previously reported as having critical roles in both mouse and human ES cells [23].
The absolute peak score occurs for substrings drawn from within the N-terminal 60 residues; 56 of the 58 most closely related homologous subsequences as scored by BLAST come from genomes that also encode the mycofactocin system.
For further analyses, we selected the score that gives the best motif content in top-scoring peaks: the peak height score for PR and CEBPA, and the read count score for CTCF and NRSF.
The dataset provides various information about each peak, including the peak score, the peak center (for STAT1), and the Q-value that reflects the significance of the peak.
The peak score gives a ranking for all peaks, whereas the P-value is used to select a subset of candidate peaks with certain significance.
We compared all models against our reference model with SCRF alone, and added a peak scoring approach for comparison with the literature.
Using ChIP-Seq data for PR, CTCF, CEBPA and NRSF, we have shown that the peak score provides an appropriate ranking for peaks.
