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In contrast, the BPC cohort's hazard rate for responders peaked higher compared to nonresponders, while the time of peak hazard rate is also delayed in responders compared to nonresponders.
CMAX; peak hazard.
TMAX; time (days) to peak hazard).
However, for NovoTTF-100A responders, the peak hazard rate was lower than that for nonresponders and the time of peak hazard rate was delayed compared to nonresponders.
Confidence in the TARGIT-A trial 4 year results is high because the peak hazard for local recurrence in the trial is between 2 and 3 years.
The results in both cohorts indicate that responders had a delay in tumor progression, but the higher peak hazard rate in the BPC cohort may be due to their tumor progression at nearly simultaneous time.
Similar(48)
Comparing to trials with similar postmenopausal populations and longer follow-up periods, we see peak hazards at similar times.
The adjuvant arimidex versus tamoxifen versus combination study, as well as the early breast cancer trials meta-analysis also show early peak hazards for local risk of recurrence (LRR) between 2 and 3 years and within 2 years, respectively.
Confining our attention to patients of Chinese origin, we were able to confirm the presence of a double peak but, compared with the data reported by Demicheli and coworkers [ 5], these peaks occurred at slightly different timings (2.5 and 9.0 years, with corresponding peak hazards of 0.041 and 0.059; Figure 3a).
A sharp two-peaked hazard function was observed for node-positive pre-menopausal patients, whereas results from node-positive post-menopausal women always displayed a single broad peak.
This "signal" is the early peak of hazard for relapse that follows surgery within 12 to 24 months, whereas the near constant hazard thereafter might be the "echo" of the natural history of breast cancer left unperturbed by surgical interference.
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CEO of Professional Science Editing for Scientists @ prosciediting.com