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Reference values from Jones et al.[ 27] were used for peak exercise testing.
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In this study, the 6MWD correlated more strongly with daily METs than did peak work rate, demonstrating the 6MWD may better reflect daily physical activity than a peak exercise test.
Furthermore, haemoglobin will be measured using Hb201+ (HemoCue, Denmark), and haemoglobin levels below 5.5 mmol/L will disqualify patients from VO2-peak exercise testing.
The eligibility requirements were determined through clinical history assessment, physical examination, blood pressure measurement, biochemical blood analyses, resting electrocardiogram, and peak cardiopulmonary exercise testing.
In accord with their known pharmacological effects, dobutamine and dipyridamole tests induced a greater reduction in SVR from rest to peak exercise than exercise tests, 2 e), and 2(f)) [ 1, 24].
Main Outcome Measures: Spirometric measurements of oxygen uptake and anaerobic threshold obtained from a peak exercise treadmill test using the modified Bruce protocol.
Baseline testing during Baseline Visit 2 will include questionnaire completion, a Self-Paced Walking Test, balance testing, a neurological examination, and peak VO2 exercise test on a cycle ergometer.
An individualized continuous submaximal bout of exercise was performed for 40 min on a cycle ergometer (CG400 model, Inbrasport; Porto Alegre, RS, Brazil) at an intensity corresponding to 80% of the ventilatory threshold, which was observed in the previous peak cardiopulmonary exercise test.
Eligible patients with HFpEF were at least 60 years of age with subjective exercise limitation owing to breathlessness or fatigue and objective evidence of exercise limitation as a measured o2 peak on cardiopulmonary exercise testing of <80% predicted for age and sex, with an appropriate pattern of gas exchange.
Both Peak Oxygen Uptake (peak VO2), from cardiopulmonary exercise testing (CPET) and the distance walked during a Six-Minute Walk Test (6 MWD) are used for following the natural history of various diseases, timing of procedures such as transplantation and for assessing the response to therapeutic interventions.
Previous studies have demonstrated abnormal responses or reductions in peak exercise capacity during cardiopulmonary exercise testing [ 5- 7] in people with ARPD.
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