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The drag-reduction mechanisms of microgrooves in water and surfactant solution were illustrated by the competition between the "peak effect" and the "restriction effect" of microgroove.
The peak effect and time course of ΔΔQTcP for moxifloxacin over 25 h were consistent with that observed in other TQT studies (data not shown) [ 24].
Insulin glulisine is an RAI analogue that displays a more rapid onset, an earlier peak effect, and a shorter duration of action than RHI [ 3, 11], with uniform absorption and efficacy among wide ranges of body mass indexes (BMIs) [ 12].
Nevertheless, both long-acting insulin analogs (detemir and glargine) have a limited peak effect and a longer mean duration of action compared with NPH insulin (with glargine having a slightly longer action than detemir [ 13, 16, 17]).
U-500 insulin is intermediate in onset of action between regular and NPH insulin (30), and in a study presented at the conference, Jackson et al. (abstract 014-LB) confirmed the prolonged time to peak effect and longer duration of action of U-500 vs. human regular U-100 insulin.
Similar(55)
Volume kinetics is a pharmacokinetic approach describing the peak effects and clearance of intravenously infused fluids.
The POMS questionnaire was applied at baseline and peak effects, and the HRS questionnaire was completed only at 6 h after dose (summary of the 0 6 h effects).
The results of the subjective effects scales were compared with paired Student's t-test (baseline versus peak effects and baseline versus 6 h, depending on the questionnaire).
Saliva samples were collected with a Salivette device at baseline (prior to self-administration), 1.5 h after administration (peak effects), and 6 h after administration.
Measurements were carried out at baseline (prior to 2C-B self-administration) between 1.5 3 h (peak effects) and 6 h after dose.
A large number of visual analogue scales (VAS) and questionnaires (ARCI and VESSPA) to evaluate subjective effects were completed at base line, peak effects, and 6 h (summary of the 0 6 h effects).
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