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43 The timing of IRAEs is variable and might depend on peak dosing and area under the curve of the drug.
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In the present study, no damage was visualized by MRI in 4 control rats irradiated by intersecting, non-interlacing arrays which created 700Gy microplanar peak doses spaced by 200 µm on-center (valley dose of 12.5 Gy at 1 cm depth).
No differences were observed in the rate of cardiotoxicity as a result of different doxorubicin peak doses [ 31].
On average, open-field plans contained peak doses of 117%, optimally wedged-plans contained peak doses of 113%, and custom-compensated plans contained peak doses of 105%.
We also compute optimal allocation to estimate the minimum effective and peak doses in discrete dose space using isotonic regression.
We consider a problem of estimating the minimum effective and peak doses in the presence of covariates.
The capsules will reach peak doses of ∼1.59 and ∼4.76 dpa, respectively, at temperatures of 900, 1200, and 1500 °C.
This decision was based on the assumption that potential high peak doses of the pollutants could contaminate the plant.
The accumulated dose and peak dose rate per pass are more difficult to assess due to uncertainties in shield distributions and directionality of the source term.
Table 5 Misdetection fraction ( 27 ) of the noisy (denoised) images Input Peak Dose [C/cm 2 ] ρ − np-l16 np- π N16 np- π U16 Silicon (disloc).
Results on c-optimality are also obtained for estimating the peak dose and the EC50 (the treatment with response half way between the control and the peak response on the increasing portion of the response function).
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