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In the first group, rats received a high peak dose of 3500 ng TCDD/kg twice per week in the first week followed by a lower TCDD dose of 81 ng/kg twice per week for the remainder of the study.
Although the differences did not reach statistical significance, the median cumulative opioid dose adjusted for weight, the median daily peak dose of opioid and the median duration of opioid exposure were higher in the IWS-positive group than in the IWS-negative group.
Rates of responding were very low during saline substitution and were highest at the peak dose of 10 µg/kg per injection of nicotine.
The mean peak dose of carvedilol was 26.5 ± 21.1 mg/day and bisoprolol was 5.8 ± 3.0 mg/day.
The continuous infusion group had propofol titrated to peak dose of 4.8 mg/kg per hour (80 μg/kg per minute).
In the intermittent group lorazepam was administered with usual dose ranges of 2 to 4 mg every 4 hours; a peak dose of 8 mg was considered acceptable.
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On average, open-field plans contained peak doses of 117%, optimally wedged-plans contained peak doses of 113%, and custom-compensated plans contained peak doses of 105%.
The capsules will reach peak doses of ∼1.59 and ∼4.76 dpa, respectively, at temperatures of 900, 1200, and 1500 °C.
This decision was based on the assumption that potential high peak doses of the pollutants could contaminate the plant.
Regarding the LiDCO™ plus, the reliability of the lithium calibration system may be negatively affected by high peak doses of muscle relaxants, which cross-react with the lithium sensor.
Most phase III studies performed in recent years have tested the addition of one concept (e.g. increase in peak dose, use of high-dose chemotherapy plus autologous haematopoietic stem cell support, or the addition of a single new drug) to standard therapies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com