Two 6 mm-radius sphere seeds based on the peak coordinates were then designed for GCA.
Table S2 shows the peak coordinates of these ROIs for each individual participant.
Mitchell [73] gives an overview of all different peak coordinates associated with the temporal parietal junction.
The reported foci were treated as localization probability distributions centered at the given Y and Z peak coordinates [36].
Because this approach utilized only peak coordinates it was relatively immune to differences in power across the experiments.
Peak coordinates were identified at p<0.05, False Discovery Rate corrected (FDR), in regions encompassing at least 10 voxels.
Of note the peak coordinate of the structural correlations is found in the right hemisphere whereas the functional peak coordinates are located in the left hemisphere.
For the region of interest (ROI) analysis, peak coordinates were based on previous research and anatomical restrictions as indicated in the results section.
This bilateral activation included the intraparietal regions [PD vs. PC, p<0.05 corrected; left and right peak coordinates, (−16, −64, 58) and (22, −68, 52); Figure 3A].
The region of blunted activation is at the height of and appears to include the ventral tegmental area and the substantia nigra, although the peak coordinates do not coincide with these regions.
Contrary to the hypothesis, the contrast of contempt versus disgust yielded significant stronger amygdala activation for disgust relative to contempt, 7 voxels, peak t-value 4.06, peak coordinates 31, −3, −11.
