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Kinetic studies revealed peak activation of the proteasome within 15 min following IGF-I stimulation.
The peak activation of muscle protein synthesis is reported to be proportional to the leucine content of the meal [34].
Frequencies that bring about highest rms (average) activation and peak activation of component MAPKs are optimal for subunit gene expression.
The peak activation of Akt occurred at 15 min. However, apelin had no effects on the activation of c-jun N-terminal kinases (JNK) or p38 MAP kinases (p38), and none of their phosphorylated forms were detected.
Apelin stimulated the activity of a specific MAPK, namely ERK, in CVSMCs 5 min after incubation began, as demonstrated by an increase in phosphorylated ERK (p-ERK) levels; the peak activation of ERK occurred at 15 min (Fig. 4A).
We also found striatal dysfunction during the decision phase, wherein peak activation of the putamen/GP was normal in PD, yet sustained longer relative to the control group; caudate activity was also sustained, but temporally lagged and attenuated.
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In addition, a bootstrap analysis identified a reliable 6 10 mm spatial displacement between the peak activations of the two tasks; the same magnitude and direction of displacement was observed in within-subjects comparisons.
This allowed us to estimate how much peak activation for each of the conditions varied from the main effect of reading.
For those clusters of activation showing a significant main effect of diagnostic group, an exploratory post-hoc analysis was conducted using analogous repeated-measures ANOVA models on the cluster peaks of activation to explore the direction of the group differences, by extracting the beta estimate of activation at the voxel of peak activation for each cluster.
Figure 3 presents time course graphs of peak activation for the oxy-Hb, deoxy-Hb and total-Hb in the frontal cortex.
The distance (in the anterior-posterior dimension) between the loci of peak activation for the knee and ankle was defined as ankle peak coordinate minus knee peak coordinate for each participant.
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